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Search Results for " granzyme b "

6

抑制剂 & 化合物

1

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36333	Z-IETD-AFC
	Z-IETD-AFC 是 caspase-8 和颗粒酶 B 的荧光底物，可用于定量半胱天冬酶-8 或颗粒酶 B 的活性。
T80745	Z-Ala-Ala-Asp-CMK Z-AAD-CMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) 是选择性granzyme B 抑制剂。
TP1128	Ac-IEPD-AFC IEPD
	Ac-IEPD-AFC (IEPD) is a substrate of Granzyme B.
T83181	Ac-IETD-AMC
	Ac-IETD-AMC为乙酰基（Ac）修饰的荧光caspase-8/颗粒酶B底物，常用于检测caspase-8活性。
T78586L	Ac-IETD-CHO TFA Ac-IETD-CHO TFA（191338-86-0 Free base )	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Ac-IETD-CHO TFA 是一种 granzyme B 和 caspase-8 抑制剂，通过阻断 caspase3 前体裂解抑制 caspase8 活性。Ac-IETD-CHO TFA 抑制 Fas 介导的细胞凋亡(Apoptosis)。
T78586	Ac-IETD-CHO	Apoptosis	Apoptosis
	Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂，能够阻止Fas介导的(Apoptosis)、出血和肝衰竭，并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。

化合物

Cat.No: T36333

Z-Ala-Ala-Asp-CMK

Cat.No: T80745

Synonym: Z-AAD-CMK

Target: Caspase

Cat.No: TP1128

Synonym: IEPD

Cat.No: T83181

Ac-IETD-CHO TFA

Cat.No: T78586L

Synonym: Ac-IETD-CHO TFA（191338-86-0 Free base )

Target: Apoptosis, Caspase

Cat.No: T78586

Target: Apoptosis

Cat. No.	Product Name	Target	Signaling Pathways
TC0036	Compound Lup-20(29)-en-3-yl acetate	IL Receptor; VEGFR; Others; TNF; COX	Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物，通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。

天然产物

Compound Lup-20(29)-en-3-yl acetate

Cat.No: TC0036

Target: IL Receptor, VEGFR, Others, TNF, COX

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00817	Granzyme B/GZMB Protein, Human, Recombinant (His) CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,...	Human	HEK293 Cells
	Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G...
TMPJ-00770	Granzyme B/GZMB Protein, Mouse, Recombinant (His) Gzmb,Cytotoxic cell protease 1,Fragmentin-2,CTLA-1,...	Mouse	HEK293 Cells
	Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
TMPH-01412	Granzyme B Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Granzyme B Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.0 kDa and the accession number is P10144.
TMPJ-01253	Serpin A3N Protein, Mouse, Recombinant (His) Serpina3n,Serine protease inhibitor A3N,Spi2,Serpin...	Mouse	HEK293 Cells
	Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic ...
TMPY-00818	Granzyme H/GZMH Protein, Human, Recombinant (His) CTSGL2,CSP-C,CCP-X,granzyme H,CTLA1,CGL-2,GZMH	Human	HEK293 Cells
	Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/...
TMPY-02210	Serpin B9 Protein, Human, Recombinant (His) CAP-3,PI-9,CAP3,PI9,serpin peptidase inhibitor, cla...	Human	Baculovirus Insect Cells
	SerpinB9, also known as Cytoplasmic antiproteinase 3, CAP-3, Peptidase inhibitor 9, SERPINB9 and PI-9, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 / PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB), the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protect these cells against the actions of gran...
TMPK-00636	BID Protein, Mouse, Recombinant (His) BID,p22 BID	Mouse	E. coli
	Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. Bid is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. Bid is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals.
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain Protein Interleukin-1...	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPK-01413	H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi) H-2K,OVA,MHC,H2-K1	Mouse	HEK293 Cells
	Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se...
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) SARS-CoV-2 epitope,MHC	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,SARS-CoV-2 epitope	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

重组蛋白

Granzyme B/GZMB Protein, Human, Recombinant (His)

Cat.No: TMPY-00817

Species: Human

Expression System: HEK293 Cells

Granzyme B/GZMB Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00770

Species: Mouse

Expression System: HEK293 Cells

Granzyme B Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01412

Species: Human

Expression System: E. coli

Serpin A3N Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01253

Species: Mouse

Expression System: HEK293 Cells

Granzyme H/GZMH Protein, Human, Recombinant (His)

Cat.No: TMPY-00818

Species: Human

Expression System: HEK293 Cells

Serpin B9 Protein, Human, Recombinant (His)

Cat.No: TMPY-02210

Species: Human

Expression System: Baculovirus Insect Cells

BID Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00636

Species: Mouse

Expression System: E. coli

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)

Cat.No: TMPK-01413

Species: Mouse

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01412

Species: Human

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01416

Species: Human

Expression System: HEK293 Cells

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